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Development of a microcontroller-based automatic control system for the electrohydraulic total artificial heart

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4 Author(s)
Hee Chan Kim ; Artificial Heart Res. Lab., Seoul Nat. Univ., South Korea ; Khanwilkar, P.S. ; Bearnson, G.B. ; Olsen, D.B.

An automatic physiological control system for the actively filled, alternately pumped ventricles of the volumetrically coupled, electrohydraulic total artificial heart (EHTAH) was developed for long-term use. The automatic control system must ensure that the device: (1) maintains a physiological response of cardiac output, (2) compensates for any nonphysiological condition, and (3) is stable, reliable, and operates at a high power efficiency. The developed automatic control system met these requirements both in vitro, in week-long continuous mock circulation tests, and in vivo, in acute open-chested animals (calves). Satisfactory results were also obtained in a series of chronic animal experiments, including 21 days of continuous operation of the fully automatic control mode, and 138 days of operation in a manual mode, in a 159-day calf implant.

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Biomedical Engineering, IEEE Transactions on  (Volume:44 ,  Issue: 1 )