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To avoid traffic accidents caused by driver's fatigue, this paper designs a fatigue detection system based on ADSP-BF548 and relative algorithm. It captures driver's images in real time by on-board camera and localizes driver's eye position via frame-difference projection, edge extracting, and template matching such kind of methods. At last, makes a warning in time according to the eye states in a period of time. The experiment shows this driver fatigue detection system based on ADSP-BF548 is of high accuracy.