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Collaborative product development has become important business strategy. In this paper, a framework for autonomous collaborative product development, in which a set of intelligent agents handle major interact tasks based on ontology, is presented. By wrapping engineering applications using agents, the framework applies generalized knowledge repository to leverages relative resources, knowledge and designer in a collaborative way. The detailed application functionality and structure of agents is studied. Finally, communication process between agents is provided, which identifies distributed participators enable to share heterogeneous data via messages of agents.