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Application of a real-time, calculable limiting form of the Renyi entropy for molecular imaging of tumors

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8 Author(s)
Marsh, J.N. ; Dept. of Math., Washington Univ. in St. Louis, St. Louis, MO, USA ; Wallace, K.D. ; McCarthy, J.E. ; Wickerhauser, M.V.
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Previously, we reported new methods for ultrasound signal characterization using entropy, Hf; a generalized entropy, the Renyi entropy, If(r); and a limiting form of Renyi entropy suitable for real-time calculation, If,∞. All of these quantities demonstrated significantly more sensitivity to subtle changes in scattering architecture than energy-based methods in certain settings. In this study, the real-time calculable limit of the Renyi entropy, If,∞, is applied for the imaging of angiogenic murine neovasculature in a breast cancer xenograft using a targeted contrast agent. It is shown that this approach may be used to reliably detect the accumulation of targeted nanoparticles at five minutes post-injection in this in vivo model.

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Ultrasonics, Ferroelectrics, and Frequency Control, IEEE Transactions on  (Volume:57 ,  Issue: 8 )