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Designing effective professional development experiences for pre-service teachers under technology-enhanced inquiry instruction is the goal of teaching skill training curriculum, explore information under the environment of teachers' professional development mode of education has become the focus of research problems. This study analyzes the meaning about the integration of information technology (IT) with chemical instructional skill curriculum and the basic requirement, then discusses the practice procedure of the integration of information technology and chemistry teaching skill curriculum. The formation of chemistry skill need several stages such as performance, imitation, training and automation, there are three different fields of chemistry teaching skill course instruction targets level settings: the skill of teaching analysis, the skill of teaching design and the skill of teaching assessment. Using case teaching and IT, this curriculum teaching reform has been performed 5 years from 2005 to 2009 and developed pre- service teachers' chemistry teaching abilities of their designing, co-operation and so on. In addition, it is important for teachers to improve abilities of IT integration, which will benefit the teaching effectiveness in high school.