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Qualitative Analysis of Gene Regulatory Networks by Satisfiability Checking of Linear Temporal Logic

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4 Author(s)
Ito, S. ; Dept. of Comput. Sci., Tokyo Inst. of Technol., Tokyo, Japan ; Izumi, N. ; Hagihara, S. ; Yonezaki, N.

We developed a method for analyzing the dynamics of gene regulatory networks in purely qualitative fashion. In our method, constraints for possible behaviors of a network and a biological property of interest are described as Linear Temporal Logic formulas, being automatically analyzed by satisfiability checking. In this way, we can investigate whether there exists some behavior which satisfies a specified property or whether all the behaviors satisfy a specified property, which are difficult in quantitative analysis.

Published in:

BioInformatics and BioEngineering (BIBE), 2010 IEEE International Conference on

Date of Conference:

May 31 2010-June 3 2010

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