By Topic

Microbubbles Conjoining LyP-1 as a Tumor Probe for Ultrasound Molecular Imaging: Targeting Efficiency Evaluation on Microfluidic Platform

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Xiang Li ; Paul Lauterbur Center for Biomed. imaging, Chinese Acad. of Sci., Shenzhen, China ; Qiaofeng Jin ; Chunxiang Jiang ; Zhanhui Wang
more authors

Microbubbles promise not only as effective acoustic probes for ultrasonic molecular imaging,but also as drug carrier vehicles by conjuncting to specific antibody or ligand. Microbubble's targeting efficiency to certain cells or moleculars is one of the major challenges of being as the acoustic probes. In this study, we developed tumor targeted contrast microbubbles by binding LyP-1 (a cyclic nonapeptide acid peptide) targeted to cancer cell. In addition, we utilized microfluidic technology to evaluate the targeted capability and efficiency of microbubbles to tumor cell surface. The system includes 8×8 chamber microfluidic array and each chamber contains eight micro cell sieves which is semicircular for cell trapping. Assisted with the controllable fluid shear stress, the microbubble's targeted to the cell and the corresponding affinity efficiency could be quantitatively evaluated under a florescent microscope. The result demonstrated that LyP-1 is an efficient maker to be congjuated with microbubbles as tumor targeting probe. Moreover, this system is shown as a useful low-cost and high efficient in vitro platform for studying ultrasonic molecular imaging, drug-delivery and therapy.

Published in:

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Date of Conference:

18-20 June 2010