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Cross-Talk Calibrating Based on Correlation Analysis in High-Throughput Genome Sequencing

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5 Author(s)
Bing-gang Ye ; Sch. of Biosci. & Bioeng., South China Univ. of Technol., Guangzhou, China ; Xiao-ming Wu ; Li Jing-Xiang ; Zhou Yan
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The images, in high-throughput genome sequencing of sequencing by synthesize, consist of A, C, G, T base fluorescence images, and the fluorophore emission spectra partially overlap, which causes cross-talk problem. This paper presents a method of correlation analysis, construct the calibration matrix to eliminate interference of the fluorophore. The experiment result shows the method provided in this article is effective to correct cross-talk influence, and get the deconvolution of the clusters signal.

Published in:

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Date of Conference:

18-20 June 2010