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Optimization of the Operational Parameters for Oestrone Quantification in Sewage and River Water Matrices Using Response Surface Method

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4 Author(s)
Wan Qiaoling ; Key Lab. of Three Gorges Reservoir Region's Eco-Environ. under Minist. of Educ., Chongqing Univ., Chongqing, China ; Yang Chun ; Zhang Zhi ; Lian Peng

Response surface method (RSM) is a set of mathematical and statistical methods for experimental design and evaluating the effects of variables and searching optimum conditions of variables to predict targeted responses. Oestrone (E1) is one of the most important steroid estrogens in sewage and waterbody. An internal standard method of HPLC-MS-MS for E1 is established with its operational parameters in the multiple reaction monitoring (MRM) mode being optimized by RSM. With a sample pretreatment using two-step solid phase extraction (SPE), the detection limit of the method was 0.5 ng/L.

Published in:

Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on

Date of Conference:

18-20 June 2010