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In the operation of central AC (air conditioning) systems, the energy consumption of chillers account for a large amount of proportion. Different numbers and capacities of chillers and their auxiliary facilities will lead to different operating energy consumption. A reasonable installation scheme of chillers and their auxiliary facilities is of great significance in reducing the total energy consumption of central AC systems. In this paper, with the help of an existing building located in Baoding, China, dynamic simulation to the operation of a central AC system in summer is carried through. First, the mathematical models of the parameters of the main facilities are established, and the electric power consumption simulation modules of the central AC system are set up by using the Matlab/Simulink tool. Second, four installation schemes of main facilities are introduced and the simulated electric power consumption curves of operation are obtained. Finally, through the analysis to the simulated results, the optimal installation and operation scheme of AC system are proposed. The work will be good references to the system design and operation, as well as the system retrofit of central AC systems to achieve the operating energy conservation.