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We propose and numerically analyze three novel reconfigurable logic cells (reconfigurable NAND/NOR, NAND/XNOR, and XNOR/XOR cells) based on single-electron transistor (SET) and MOSFET hybrid circuits. These reconfigurable cells can work normally at room temperature with high flexibility and performance. Compared with pure MOSFET circuits, the cells proposed in this paper can flexibly realize many more functions with high performance at much lower costs of area and power. Additionally, compared with pure SET circuits, the hybrid SET/MOSFET circuits can achieve higher voltage swing. Finally, the reconfigurable logic cells consisting of SETs and MOSFETs are very useful for the very large scale integration based on SETs.