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Depth-Resolved Blood Oxygen Saturation Assessment Using Spectroscopic Common-Path Fourier Domain Optical Coherence Tomography

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2 Author(s)
Xuan Liu ; Dept. of Electr. & Comput. Eng., Johns Hopkins Univ., Baltimore, MD, USA ; Kang, J.U.

Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength-distance-dependent point spread function (PSF) of OCT's. Second, to reduce the spectral speckle noise due to the highly scattering blood, we have implemented a spatial low-pass filter to the 2-D OCT dataset consisting of spectra obtained at different lateral positions. We have assessed the effectiveness of these methods using common-path OCT system. Results showed that we were able to extract unambiguous depth-resolved, SO2-dependent spectroscopic information from 1-D and 2-D OCT images, which could be used to accurately assess the SO2 level.

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Biomedical Engineering, IEEE Transactions on  (Volume:57 ,  Issue: 10 )