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In this paper, we extend the cubature Kalman filter (CKF) to deal with nonlinear state-space models of the continuous-discrete kind. To be consistent with the literature, the resulting nonlinear filter is referred to as the continuous-discrete cubature Kalman filter (CD-CKF). We use the Itô-Taylor expansion of order 1.5 to transform the process equation, modeled in the form of stochastic ordinary differential equations, into a set of stochastic difference equations. Building on this transformation and assuming that all conditional densities are Gaussian-distributed, the solution to the Bayesian filter reduces to the problem of how to compute Gaussian-weighted integrals. To numerically compute the integrals, we use the third-degree cubature rule. For a reliable implementation of the CD-CKF in a finite word-length machine, it is structurally modified to propagate the square-roots of the covariance matrices. The reliability and accuracy of the square-root version of the CD-CKF are tested in a case study that involves the use of a radar problem of practical significance; the problem considered herein is challenging in the context of radar in two respects- high dimensionality of the state and increasing degree of nonlinearity. The results, presented herein, indicate that the CD-CKF markedly outperforms existing continuous-discrete filters.