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Activities of daily living are important for assessing changes in physical and behavioural profiles of the general population over time, particularly for the elderly and patients with chronic diseases. Although accelerometers are widely integrated with wearable sensors for activity classification, the positioning of the sensors and the selection of relevant features for different activity groups still pose interesting research challenges. This paper investigates wearable sensor placement at different body positions and aims to provide a framework that can answer the following questions: (i) What is the ideal sensor location for a given group of activities? (ii) Of the different time-frequency features that can be extracted from wearable accelerometers, which ones are most relevant for discriminating different activity types?