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To maximize the performance of emerging multi- and many-core accelerators such as the IBM Cell B.E. and the NVIDIA GPU, a Memory Centric Kernel Framework (MCKF) was developed. MCKF allows a user to decompose the physical space of an application based on the available fast memory in the accelerators. In this way, reducing the communication cost in accessing data can maximize the extraordinary computing power of the accelerators. MCKF is both generic and flexible because it encapsulates hardware-specific characteristics. It has been implemented and tested for short-range inter-active particle simulation on IBM Cell B.E. blades.