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In this work, a portable real-time wireless health monitoring system is developed. The system is used for remote monitoring of patients' heart rate and oxygen saturation in blood. The system was designed and implemented using ZigBee wireless technologies. All pulse oximetry data are transferred within a group of wireless personal area network (WPAN) to database computer server. The sensor modules were designed for low power operation with a program that can adjust power management depending on scenarios of power source and current power operation. The sensor unit consists of (1) two types of LEDs and photodiode packed in Velcro strip that is facing to a patient's fingertip; (2) Microcontroller unit for interfacing with ZigBee module, processing pulse oximetry data and storing some data before sending to base PC; (3) ZigBee module for communicating the data of pulse oximetry, ZigBee module gets all commands from microcontroller unit and it has a complete ZigBee stack inside and (4) Base node for receiving and storing the data before sending to PC.