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The definition of vaccine, vaccine autonomous obtaining algorithm, vaccination operator and evolution of vaccine library are proposed in this paper. The generic clonal selection algorithm is improved by integrating with vaccine autonomous obtaining and vaccination operator, whose purpose is to accelerate the convergence speed of clonal selection algorithm, and improve the efficiency of the algorithm. The improved clonal selection algorithm together with negative selection mechanism in immunology is used to create the model of network intrusion detection. Simulated experimental results and theoretical computation efficiency analyses demonstrate the availability of the model and the speedup of convergence.