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We present an optical fiber catheter-based complex swept-source optical coherence tomography (OCT) system for imaging of biomedical turbid tissue. A quadrature Mach-Zehnder interferometer based on multi-port fiber couplers was employed in our complex swept-source OCT system. A variety of fiber probes were developed for the different types of biomedical application. We demonstrate OCT images of human skin and deeper tissues by using the fiber probes and our OCT engine. The results show that catheter-based swept source OCT is an effective imaging modality for real-time diagnosis and in vivo applications on human turbid tissue.