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In this paper, we investigate the optimization problem of resource allocation in downlink of multiuser MISO-OFDM system. Multiple users with different BER and minimum transmission rate requirements are considered. We propose a novel heuristic allocation algorithm (HAA) of radio resource, which minimizes the total transmit power of the base station while meeting individual users'QoS requirements. The proposed algorithm combines antenna selection, subcarrier, bit and power allocation together, pre-estimating number of subcarriers assigned to each user and number of bits loaded for each subcarrier to reduce search number, reducing about 8 dB average bit SNR comparing with fixed allocation algorithm (FAA), and acquiring asymptotic average bit SNR of optimal allocation algorithm (OAA) with much lower complexity.