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As the advanced phase of development of E-Business, Collaborative Business needs a powerful network platform to support the complex interaction and collaboration inside or outside of it. Grid for the purpose of a network platform that has powerful computing ability can provide a variety of services, and can support various interactions. It is also open and can deal with heterogeneous and distributed resources. In the following paper the model of Collaborative Business under internet environment is presented and a conceptual framework for a Collaborative Business platform is built based on Grid Computing with the idea of Service Oriented Architecture (SOA). SOA realized the collaboration among E-Business systems and the internal systems of enterprises and the cooperation among enterprises in the supply chain. The conceptual framework also provides cooperative channels for the enterprises, partners, customers and government departments. The interfaces of collaborative systems are encapsulated by the Grid Service and the E-Business is transacted by finding, integrating and invoking of the grid service.