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In recent years, Ultra-Wideband (UWB) technology has emerged as a promising physical layer candidate for a wide range of wireless networks, especially due to its low operation power level and coexistence ability with traditional wireless systems. However, none of these physical layer realizations has specified the compatible operation among them (see, e.g.,). Therefore, the effective interoperability between asymmetric UWB transceivers needs to be considered for ubiquitous wireless communications. In this paper, we investigate the transceiver design for asymmetric UWB links with a single transmitter and a single receiver. We consider factors that can lead to the asymmetry between UWB transmitters and receivers such as different numbers of signal bands and different pulse rates. Our analysis reveals the similarity between the asymmetric UWB links and the conventional multiantenna systems. Then, MIMO signal processing approaches can be readily applied to achieve the optimal design in terms of channel throughput or bit error rate (BER). Analysis and simulations corroborate the effectiveness of our transceiver designs.