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Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule.
Published in:
Applied Physics Letters
(Volume:96
,
Issue:
21
)
Date of Publication: May 2010
- Page(s):
- 213701 - 213701-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.3431628
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 27 May 2010
- Issue Date :
- May 2010
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