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Single DNA molecule detection in an optical trap using surface-enhanced Raman scattering

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7 Author(s)
Rao, Satish ; ICFO–Institut de Ciències Fotòniques, Mediterranean Technology Park, 08860 Castelldefels, Barcelona, Spain ; Raj, Saurabh ; Balint, Stefan ; Fons, Carlota Bardina
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Raman spectra from single DNA molecules in their natural aqueous environment are presented. A DNA molecule that is anchored between two optically trapped dielectric beads is suspended in a solution with nanosized silver colloid particles. The nonspecific binding of the metal to the DNA enhances the Raman scattering that is excited by a near-infrared beam. A Raman spectrum is first recorded followed by a force-extension curve that verifies the presence of a single DNA molecule.

Published in:

Applied Physics Letters  (Volume:96 ,  Issue: 21 )