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An in-vivo body network is an interconnection of implanted medical devices without a wired or wireless connection. In this paradigm, the body's own circulatory network is utilized as the channel. Instead of electrical or electromagnetic signals, inert nano particles are used as the signal carrier. A framework for in-vivo communication along with a computer based model is developed. Simulation results with a transmitter and receiver placed at two ends of the human aorta is presented. Blood vessels behave similar to electromagnetic channels. Re-circulation and dispersion results in inter symbol interference (ISI) and delay spread. On-off keying (OOK) modulation with receiver equalization is shown to provide a reliable in-vivo communication link.