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Exploring magneto-optical properties of biofunctionalized magnetic chains for developing label-free immunoassays

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4 Author(s)
Sang Yoon Park ; Quantum Nanoelectronics Research Center, Tokyo Institute of Technology, Tokyo 152-8552, Japan ; Ko, Pil Joo ; Handa, Hiroshi ; Sandhu, A.

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We describe a magneto-optical transmittance read-out method for bioassays utilizing rotating chains in a solution composed of biotinylated superparamagnetic magnetic nanobeads. Highly sensitive and fast optical transmission signals from ultradiluted magnetic fluids containing biomolcules were obtained by rotating the magnetic chains, which acted as microstirring devices. Interaction of biomolecules with functionalized magnetic nanobeads yielded longer chains of self-assembled magnetic nanobeads, resulting in an increase in the optical transmittance compared to magnetic chains formed by only magnetic dipolar interactions without biomolecules in the solution.

Published in:

Journal of Applied Physics  (Volume:107 ,  Issue: 9 )