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The achievable data rates in modern serial-link systems are limited by the intersymbol interference (ISI) caused by wire losses and package parasitics. Although more sophisticated digital communication techniques can be used to combat ISI, the lack of available multibit analog-to-digital converters (ADCs) has primarily limited their use. A promising approach to relax the ADC requirements so as to enable Nyquist-rate digitization is to channelize the received signal into multiple frequency subbands and then sample using a bank of low-frequency ADCs. In this brief, the digital processing required in such a channelized receiver is presented. The use of single-carrier cyclic prefixed communication is also proposed to reduce the computational complexity in channels with moderate-to-large ISI.