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Engineering three-dimensional nervous tissue constructs based on fiber-gel substrates

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2 Author(s)
Siriwardane, M.L. ; Dept. of Biomed. Eng., New Jersey Inst. of Technol., Newark, NJ, USA ; Pfister, B.J.

Three-dimensional (3D) nervous tissue constructs were developed using a compliant gel matrix and a fiber component for promoting contact-guided axon outgrowth. Rat embryonic (E15) dorsal root ganglion expiants (DRGs) were cultured on biodegradable poly-L-lactic acid (PLLA) and wet-spun type I collagen fibers embedded in soft collagen gels. Gel constructs containing fibers induced greater axon outgrowth distances with significantly more directionality along the aligned fibers. Interestingly, wet-spun type I collagen from rat tail tendon displayed a highly aligned outgrowth pattern from DRG axons suggesting potential use for peripheral nerve repair.

Published in:

Bioengineering Conference, Proceedings of the 2010 IEEE 36th Annual Northeast

Date of Conference:

26-28 March 2010

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