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Radio Frequency Identification (RFID) technology has been widely accepted in hospitals to track and locate newborn babies. This paper proposes a Web-based management system based on RFID tagging system in neonatal department. The centralized database system improved infant care and safety, reduced systems and human-based errors and enabled fast sharing of medical information with the clinical staff and families. Besides the system architecture and functions are described, the technologies employed in the development are briefly introduced too.