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We study the responses of a cultured neural network when it is exposed to epileptogenesis glutamate injury causing epilepsy and subsequent treatment with phenobarbital by constructing connectivity map of neurons using correlation matrix. This study is particularly useful in understanding the pharmaceutical drug induced changes in the neuronal network properties with insights into changes at the systems biology level.
Published in:
Applied Physics Letters
(Volume:96
,
Issue:
16
)
Date of Publication: Apr 2010
- Page(s):
- 163704 - 163704-3
- ISSN :
- 0003-6951
- Digital Object Identifier :
- 10.1063/1.3398025
- Product Type:
- Journals & Magazines
- Date of Current Version :
- 26 April 2010
- Issue Date :
- Apr 2010
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