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This paper introduces IBM message-oriented middleware MQ and the configuration of IBM Mainframe interface based on analyses of heterogeneous networks. And then this paper researches mechanism of the management of the internal channel processors of MAINFRAME, as well as methods to achieve the communication between MQ and applications. Thereby the key code of realizing communication is provided. Through high-density tests of the system, this paper further demonstrates and proves that applying MQ for is communication reliable and rapid.