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Logic-Based Steady-State Analysis and Revision of Metabolic Networks with Inhibition

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3 Author(s)
Oliver Ray ; Dept. Comput. Sci., Univ. of Bristol, Bristol, UK ; Ken Whelan ; Ross King

This paper presents a qualitative logic-based method for the steady-state analysis and revision of metabolic networks with inhibition. The approach is able to automatically revise an initial metabolic model - through the addition and removal of whole reactions or individual substrates, products and inhibitors - in order to ensure the existence of a steady-state behaviour consistent with a set of experimental observations. We show how this can be done in a nonmonotonic logic programming setting and discuss the challenges that arise when metabolic cycles or mutual inhibitions occur in the underlying network.

Published in:

Complex, Intelligent and Software Intensive Systems (CISIS), 2010 International Conference on

Date of Conference:

15-18 Feb. 2010