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Circadian pattern to arrhythmias in a genetic mouse model of heart failure

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5 Author(s)
Shusterman, V. ; Univ. of Pittsburgh, Pittsburgh, PA, USA ; McTiernan, C.F. ; Mehdi, H. ; Troy, W.C.
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Arrhythmias and sudden cardiac death have a circadian pattern of occurrence in humans. We hypothesized that a circadian pattern of arrhythmias is also present in transgenic mice with cardiac-specific overexpression of tumor necrosis factor alpha, which develop a dilated cardiomyopathy, arrhythmias and heart failure. To test this hypothesis, telemetry monitors were implanted and 24 hr, ambulatory ECG was recorded ¿ 5 days later. Animals were maintained on a 12 hr light/dark cycle. The incidence of ventricular arrhythmias increased between 3 pm and 12 am, whereas atrial arrhythmias surged between 4 am and 12 pm. This circadian pattern of arrhythmias is in excellent agreement with human data (taking into account a 12-hour shift between activity periods in diurnal humans and nocturnal rodents). The molecular mechanisms underlying such circadian patterns of arrhythmias were examined using gene expression analysis and mathematical modeling.

Published in:

Computers in Cardiology, 2009

Date of Conference:

13-16 Sept. 2009