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Characterization of a high-Q in-liquid longitudinal-mode film bulk acoustic resonator for real-time in-situ monitoring of competitive protein adsorption

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4 Author(s)
Choi, Seokheun ; Sch. of Electr., Comput. & Energy Eng., Arizona State Univ., Tempe, AZ, USA ; Wencheng Xu ; Xu Zhang ; Junseok Chae

We report the characterization results of in-liquid longitudinal-mode FBAR (L-FBAR) for real-time in-situ monitoring of the Vroman effect, a competitive adsorption and exchange of proteins on a surface. The change of resonant frequency of the L-FBAR, ~1.55 GHz, is a direct function of the proteins' molecular weight, and thus we monitor the resonant frequency shifts to estimate the adsorption and exchange behavior. A low molecular weight (LMW) protein, albumin, initially covers the surface and is displaced by a high molecular weight (HMW) protein, IgG; sequentially, the highest molecular weight protein, fibrinogen displaces IgG. However, the reverse sequence does not occur.

Published in:

Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on

Date of Conference:

24-28 Jan. 2010