By Topic

Ultrasound-mediated endothelial cell permeability changes with targeted contrast agents

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

2 Author(s)
Anastasiadis, P. ; Mech. Eng., Univ. of Hawaii at Manoa, Honolulu, HI, USA ; Allen, John S.

The development of site-targeted ultrasound contrast agents (UCAs), gas-filled microbubbles conjugated with targeting ligands on their surface, has provided a novel means for the detection and evaluation of intravascular pathology, cellular imaging and for ultrasound-assisted drug and gene delivery. Endothelial monolayers form the main barrier for the passage of macromolecules and circulating cells from blood to the tissues and are immediately affected by any changes in inter-endothelial gaps. Targeted microbubbles in combination with low-frequency ultrasound may directly affect the endothelial cell membranes as to increase the permeability and thus aid in the absorption of drugs into tissues. In an effort to more rigorously quantify alterations in the endothelial barrier function ultrasound-mediated changes in endothelial cell permeability are examined in real-time using an Electric Cell Substrate Impedance Sensing (ECIS) device in conjunction with ultrasound and targeted contrast agents.

Published in:

Ultrasonics Symposium (IUS), 2009 IEEE International

Date of Conference:

20-23 Sept. 2009