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In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays

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9 Author(s)
Mast, T.D. ; Dept. of Biomed. Eng., Univ. of Cincinnati, Cincinnati, OH, USA ; Barthe, P.G. ; Makin, I. ; Slayton, M.H.
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In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3 × 20 mm2 aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of ¿747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.

Published in:

Ultrasonics Symposium (IUS), 2009 IEEE International

Date of Conference:

20-23 Sept. 2009