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In the preclinical studies reported here, VX2 cancer within rabbit liver has been treated by bulk ultrasound ablation employing miniaturized image-ablate arrays. Array probes were constructed with 32 elements in a 2.3 Ã 20 mm2 aperture and employed for B-scan imaging as well as bulk ablation at 4.8 MHz. In a series of in vivo experiments, tumor ablation using these arrays was histologically confirmed, with complete ablation of tumor cross sections for exposures with delivery of Â¿747 J acoustic energy. These results show feasibility for development of an image-guided, interstitial bulk ultrasound ablation approach for clinical liver cancer treatment.