Cart (Loading....) | Create Account
Close category search window

Applications of low intensity pulsed ultrasound for functional bone tissue engineering using adult stem cells

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
Marvel, S. ; Joint Dept. of Biomed. Eng., UNC, Chapel Hill, NC, USA ; Okrasinski, S. ; Bernacki, S.H. ; Loboa, E.
more authors

Low intensity pulsed ultrasound (LIPUS) has been used extensively for fracture healing. Many LIPUS parameters have been studied in depth except for pulse repetition frequency (PRF). However, to examine this parameter, a custom LIPUS system needed to be designed since commercial systems have very little control over parameter modification. Specifically, the PRF of commercial systems is typically set to either 100 Hz or 1 kHz and cannot be changed. A custom system was used to explore the effects of PRF on human adipose derived adult stem cells (hASCs) and bone marrow derived mesenchymal stem cells (hMSCs). The PRF was found to significantly affect cellular response to LIPUS stimulation for both cell types. Additionally, LIPUS was shown to strongly accelerate osteogenic differentiation of hASCs based on amount of calcium accretion normalized by total DNA.

Published in:

Ultrasonics Symposium (IUS), 2009 IEEE International

Date of Conference:

20-23 Sept. 2009

Need Help?

IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.