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A wireless, batteryless, less invasive blood pressure sensing microsystem based on an instrumented circular cuff has been developed for advanced biological research. The proposed sensing technique avoids vessel penetration and substantially minimizes vessel restriction due to the soft cuff elasticity. The integrated electronic system design is presented with emphases on the design trade-off and system considerations. The measurement results demonstrate full functionality of the microsystems with real-time high-fidelity blood pressure sensing capability under wireless data telemetry and adaptive RF powering conditions.