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In this paper, a detailed linearization procedure for dynamic load modulation (DLM) transmitter architectures is proposed for the first time. Compared with the conventional single-input/single-output digital predistortion (DPD) approach used with traditional power amplifiers (PAs), the proposed linearization scheme is based on a regular memory DPD in combination with an efficiency-optimized static one-to-two mapping inverse model, which constructs the predistorted input signals to the DLM transmitter. The time-alignment issue, which is very important to this dual-input architecture, is also considered. The proposed technique is demonstrated by a 1-GHz 10-W LDMOS PA that employs a varactor-based tunable matching network. A normalized mean square error of -35 dB, and adjacent channel leakage ratio of -43 dBc is achieved, with an average power-added efficiency of 53% for a single-carrier WCDMA signal with 7-dB peak-to-average ratio. Finally, it is shown that the time-alignment sensitivity is relaxed when the proposed linearization scheme is used. This means that the overall complexity of the transmitter implementation can be reduced.