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In Part II of this paper, a comparison of the most representative flip-flop (FF) classes and topologies in a 65-nm CMOS technology is carried out. The comparison, which is performed on the energy-delay-area domain, exploits the strategies and methodologies for FFs analysis and design reported in Part I. In particular, the analysis accounts for the impact of leakage and layout parasitics on the optimization of the circuits. The tradeoffs between leakage, area, clock load, delay, and other interesting properties are extensively discussed. The investigation permits to derive several considerations on each FF class and to identify the best topologies for a targeted application.