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Multifunctional vectors system for cancer therapy using single-walled carbon nanotubes and antisense oligonucleotide-modified gold nanoparticles composite materials

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5 Author(s)
Yingyue Zhu ; State Key Lab. of Food Sci. & Technol., Jiangnan Univ., Wuxi, China ; Wei Chen ; Ruirui Qiao ; Zhengyu Jin
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A novel transfection vector was designed to deliver the antisense oligodeoxynucleotide into the cancer cells (HL-60). Antisense oligodeoxynucleotides (ASODNs) were conjugated to the gold nanoparticles (GNPs) through a chemical reaction. The conjugates were then bound to the single-walled carbon nanotubes (SWNTs). This vector system can effectively for induced apoptosis of the cancer cells. The gold nanoparticles helped to improve both transfection and Raman signal. This vector system can effectively for induced apoptosis of the cancer cells, and thus has the potential to be used as a cancer therapy.

Published in:

Nanoelectronics Conference (INEC), 2010 3rd International

Date of Conference:

3-8 Jan. 2010