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We obtained the bone scaffolds general constitutive and seepage governing equations based on conservation of energy and Darcy's laws under fluid-solid-thermo multi-physics fields. Furthermore, we have also established the full coupling mathematical models of bone scaffolds under fluid-solid-thermo multi-physics fields. Based on these formulae in the COMSOL finite element platform, we have analyzed the stress, strain, fluid seepage velocity and the density under different external boundary and initial conditions. Through analyzing these computing results and comparing with the real experiments data of references, we think this methodology is feasible to guild bone scaffolds and porous medium design under the fluid-solid-thermo full coupling multi-physics fields. Lastly, we can find some rules of interstitial nutrition flow and scaffolds solid material movement and biodegradation in fluid-solid-thermo full coupling multiphysics.