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SPICE Circuit Simulation of the Electrical Response of a Semiconductor Membrane to a Single-Stranded DNA Translocating Through a Nanopore

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5 Author(s)
Leroux, A. ; Dept. of Electr. Eng. & Comput. Sci., Univ. of Liege, Liege, Belgium ; Destine, J. ; Vanderheyden, B. ; Gracheva, M.E.
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In this paper, we describe a circuit-element model for the electric detection of biomolecules in translocation through a nanopore in a semiconductor-oxide-semiconductor (SOS) membrane. The biomolecules are simulated as a superposition of individual charges moving through the nanopore and inducing a charge variation on the membrane electrodes that is modeled as a current source. The SOS membrane is discretized into interconnected elementary circuit elements. The model is tested on the translocation of 11 base single-stranded C3AC7 DNA molecule, for which the electric signal shows good qualitative agreement with the multiscale device approach of Gracheva et al., while quantifying the low-pass filtering in the membrane. Overall, the model confirms the possibility of identifying the sequence of the DNA bases electrically.

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Nanotechnology, IEEE Transactions on  (Volume:9 ,  Issue: 3 )