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A MRI and Polarized Gases Compatible Respirator and Gas Administrator for the Study of the Small Animal Lung: Volume Measurement and Control

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5 Author(s)
Angelos Kyriazis ; Instituto de Estudios Biofuncionales, Universidad Complutense de Madrid, Madrid, Spain ; Rigoberto Perez de Alejo ; Ignacio Rodriguez ; Lars E. Olsson
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We have developed over the past years an experimental magnetic resonance imaging (MRI) and polarized gases compatible mechanical respirator for the study of the small experimental animal. The respirator has been successfully used for experiments both in the MRI setting for polarized 3He, 19F, and proton imaging as well as for functional measurements of the lungs. The new main pneumatic valve with the two integrated sensors for simultaneous lung pressure and volume measurements and the proportional valve to set the tidal volume of the respiration are described. It is shown how the device measures and controls the tidal volume of the lungs.

Published in:

IEEE Transactions on Biomedical Engineering  (Volume:57 ,  Issue: 7 )