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Towards ISFET based DNA logic for rapid nucleic acid detection

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4 Author(s)
Wong, W. ; Inst. of Biomed. Eng., Imperial Coll. London, London, UK ; Shepherd, L. ; Georgiou, P. ; Toumazou, C.

This paper presents a novel configuration for Ion sensitive Field Effect Transistors (ISFETs) to be used as a threshold detector during a Single Nucleotide Polymorphism (SNP) base pair match. ISFET-based inverters are used as reaction threshold detectors to convey the chemical reaction level to a logic output once a threshold has been reached. Using this, DNA logic functions are derived for nucleotides allowing identification of multiple SNPs. This logic is extended to facilitate a combination of SNPs, deriving gates which give a simple Yes/No answer to their presence. A DNA logic `NOR' gate is derived for an application where two SNPs need to absent in order to determine drug delivery.

Published in:

Sensors, 2009 IEEE

Date of Conference:

25-28 Oct. 2009