Referenced Items are not available for this document.
We report on a novel approach to identify genetic variations based on the detection of specific polymerase-chain-reaction products by surface plasmon resonance. We use a recently developed, home-made spectrometer which exploits chips with integrated optics and microfluidics. The gold film at the chip surface is locally functionalized with single-stranded, thiol-modified probe DNA by applying a nanoliter dispenser. We discuss the chemical conditions for the achievement of maximum SPR signal strength and spot array density, and evaluate the SPR detection of selective binding of a set of 17 PCR products.
Published in:
Sensors, 2009 IEEE
Date of Conference: 25-28 Oct. 2009
- Page(s):
- 392 - 395
- ISSN :
- 1930-0395
- E-ISBN :
- 978-1-4244-5335-1
- Print ISBN:
- 978-1-4244-4548-6
- INSPEC Accession Number:
- 11119170
- Conference Location :
- Christchurch
- Digital Object Identifier :
- 10.1109/ICSENS.2009.5398247
- Product Type:
- Conference Publications
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