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In neuro-inspired computing, cortical columns or microcircuits appear to be the basic unit of computation for recognition related tasks. This paper proposes an integrated framework for an efficient implementation of a cortical column on reconfigurable platform (FPGAs). A novel hardware/software co-design implementation strategy is devised and the functionality is tested in the context of speech recognition application. An overall accuracy of 98% was achieved with the fixed-point hardware/software co-design technique in comparison to the 100% with the floating-point software implementation.