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This paper explores the interdependencies between buffer size, throughput, latency and packet loss in runtime adaptable network-on-chips. Based on the SystemC simulation model of a runtime reconfigurable system-on-chip, buffer sizes of switches and of network interfaces were adjusted to find the optimal relation between throughput, latency and packet loss. A synthetic traffic generator parameterised according to characteristics of traffic patterns in networking applications provides the stimulus for the simulation. Simulation results show that buffers for only a few packets are required within the system while most buffer memory should be provided at the system gateway.