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DNA damage and mitochondria dysfunction in cell apoptosis induced by nonthermal air plasma

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4 Author(s)
Kim, G.J. ; Department of Electronic and Electrical Engineering, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea ; Kim, W. ; Kim, K.T. ; Lee, J.K.

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Nonthermal plasma is known to induce animal cell death but the mechanism is not yet clear. Here, cellular and biochemical regulation of cell apoptosis is demonstrated for plasma treated cells. Surface type nonthermal air plasma triggered apoptosis of B16F10 mouse melanoma cancer cells causing DNA damage and mitochondria dysfunction. Plasma treatment activated caspase-3, apoptosis executioner. The plasma treated cells also accumulated gamma-H2A.X, marker for DNA double strand breaks, and p53 tumor suppressor gene as a response to DNA damage. Interestingly, cytochrome C was released from mitochondria and its membrane potential was changed significantly.

Published in:

Applied Physics Letters  (Volume:96 ,  Issue: 2 )

Date of Publication:

Jan 2010

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