Cart (Loading....) | Create Account
Close category search window
 

Identifying structural repeats in proteins using graph centrality measures

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Jain, R. ; Center for Comput. Natural, Sci. & Bioinf., IIIT, Hyderabad, India ; Yalamanchili, H.K. ; Parekh, N.

Here we apply the graph-theoretic concept of betweenness centrality to a class of protein repeats, e.g., Armadillo (ARM) and HEAT. The Betweenness of a node represents how often a node is traversed on the shortest path between all pairs of nodes i, j in the network and thus gives the contribution of each node in the network. These repeats are not easily detectable at the sequence level because of low conservation between independent repeated units, e.g., HEAT repeats are known to have less than 13% identity. Their identification at the structure level typically involves self structure-structure comparison, which can be computationally very intensive. Our analysis of a set of proteins from ARM and HEAT repeat family shows that the repeat regions exhibit similar connectivity patterns for the repeating units. Since it is generally accepted that in many networks, the larger the degree of a node, the larger the chance that many of the shortest paths will pass through this node, computing vertex Betweenness provides a simple and elegant approach for identifying tandem structural repeats in proteins.

Published in:

Nature & Biologically Inspired Computing, 2009. NaBIC 2009. World Congress on

Date of Conference:

9-11 Dec. 2009

Need Help?


IEEE Advancing Technology for Humanity About IEEE Xplore | Contact | Help | Terms of Use | Nondiscrimination Policy | Site Map | Privacy & Opting Out of Cookies

A not-for-profit organization, IEEE is the world's largest professional association for the advancement of technology.
© Copyright 2014 IEEE - All rights reserved. Use of this web site signifies your agreement to the terms and conditions.