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Graph data management for molecular and cell biology

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2 Author(s)
B. A. Eckman ; IBM Software Group, 1475 Phoenixville Pike, West Chester, Pennsylvania 19380, USA ; P. G. Brown

As high-throughput biology begins to generate large volumes of systems biology data, the need grows for robust, efficient database systems to support investigations of metabolic and signaling pathways, chemical reaction networks, gene regulatory networks, and protein interaction networks. Network data is frequently represented as graphs, and researchers need to navigate, query and manipulate this data in ways that are not well supported by standard relational database management systems (RDBMSs). Current approaches to managing graphs in an RDBMS rely on either external procedural logic to execute the graph algorithms or clumsy and inefficient algorithms implemented in Structured Query Language (SQL). In this paper we describe the Systems Biology Graph Extender, a research prototype that extends the IBM RDBMS—DB2® Universal Database software—with graph objects and operations to support declarative SQL queries over biological networks and other graph structures. Supported operations include neighborhood queries, shortest path queries, spanning trees, graph transposition, and graph matching. In a federated database environment, graph operations may be applied to data stored in any format, whether remote or local, relational or nonrelational. A single federated query may include both graph-based predicates and predicates over related data sources, such as microarray expression levels, clinical prognosis and outcome, or the function of orthologous proteins (i.e., proteins that are evolutionarily related to those in another species) in mouse disease models.

Note: The Institute of Electrical and Electronics Engineers, Incorporated is distributing this Article with permission of the International Business Machines Corporation (IBM) who is the exclusive owner. The recipient of this Article may not assign, sublicense, lease, rent or otherwise transfer, reproduce, prepare derivative works, publicly display or perform, or distribute the Article.  

Published in:

IBM Journal of Research and Development  (Volume:50 ,  Issue: 6 )