By Topic

Weighted Consensus Clustering for Identifying Functional Modules in Protein-Protein Interaction Networks

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Yi Zhang ; Sch. of Comput. Sci., Florida Int. Univ., Miami, FL, USA ; Erliang Zeng ; Tao Li ; Narasimhan, G.

In this article we present a new approach - weighted consensus clustering to identify the clusters in Protein-protein interaction (PPI) networks where each cluster corresponds to a group of functionally similar proteins. In weighed consensus clustering, different input clustering results weigh differently, i.e., a weight for each input clustering is introduced and the weights are automatically determined by an optimization process. We evaluate our proposed method with standard measures such as modularity, normalized mutual information (NMI) and the Gene Ontology (GO) consortium database and compare the performance of our approach with other consensus clustering methods. Experimental results demonstrate the effectiveness of our proposed approach.

Published in:

Machine Learning and Applications, 2009. ICMLA '09. International Conference on

Date of Conference:

13-15 Dec. 2009